Bull Exp Biol Med. 2011 May; 151(1): 88-94
Nepomnyashchikh LM, Lushnikova EL, Molodykh NA, Klinnikova MG, Molodykh OP
The age-related features of ultrastructural reorder of cardiomyocytes were studied in rats with anthracycline-induced injury. The growth of regenerative and plastic insufficiency of cardiomyocytes in animals of various age groups was accompanied by stereotypic ultrastructural reorganization. The major changes concerned the nucleus, myofibrillar compartment, and rough sarcoplasmic reticulum. Intracellular reorder of cardiomyocytes in immature animals was observed in the same period, but included a greater decrease in the volume density of myofibrils as compared to that in aged rats. The recovery of cardiomyocyte ultrastructure in immature animals occurred in the earlier period. Cardiomyocytes of aged rats were characterized by greater structural modification of mitochondria and substantial area of lytic changes in myofibrillar bundles. Cardiotoxicity of doxorubicin in immature animals was manifested in severe destruction of the capillary endothelium, which occurred in the early period after treatment.
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