Vaccine design for CD8 T lymphocyte responses.

Cold Spring Harb Perspect Med. 2011 Sep; 1(1): a007252
Koup RA, Douek DC

Vaccines are arguably the many powerful medical intervention in the fight against spreading diseases. The enormity of the global human immunodeficiency pathogen type 1 (HIV)/acquired immunodeficiency syndrome (AIDS) pestilence makes the development of an AIDS vaccine the scientific as well as humanitarian priority. Research on vaccines that induce T-cell immunity has dominated much of the recent development effort, mostly because of disappointing efforts to induce neutralizing antibodies through vaccination. Whereas T cells are known to limit HIV as well as other pathogen infections after infection, their role in protection against initial infection is much reduction clear. In this article, you will review the motive behind the T-cell-based vaccine approach, provide an general outlook of the methods as well as platforms that are being applied, as well as plead the stroke of recent vaccine trial formula on the future direction of T-cell vaccine research.

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