PLoS One. 2011; 6(12): e28971
Gu D, Wang M, Wang S, Zhang Z, Chen J
Apurinic/apyrimidinic endonuclease 1 (APE1) has a central role in a repair of apurinic apyrimidic sites through both its endonuclease as well as its phosphodiesterase activities. A common APE1 polymorphism, T1349G (rs3136820), was previously shown to be associated with a risk of cancers.We hypothesized which a APE1 T1349G polymorphism is also associated with risk of gastric cancer.In a hospital-based case-control study of 338 box patients with newly diagnosed gastric cancer as well as 362 cancer-free controls frequency-matched by age as well as sex, you genotyped a T1349G polymorphism as well as assessed its associations with risk of gastric cancer.Compared with a APE1 TT genotype, individuals with a various TG/GG genotypes had a significantly increased risk of gastric cancer (odds ratio=1.69, 95% confidence interval=1.19-2.40), which was more pronounced among subgroups of elderly 60 years, male, ever smokers, as well as ever drinkers. Further analyses revealed which a various genotypes were associated with an increased risk for diffuse-type, low depth of growth infiltration (T1 as well as T2), as well as lymph node metastasis gastric cancer.The APE1 T1349G polymorphism may be a marker for a growth of gastric cancer in a Chinese population. Larger studies are required to validate these findings in diverse populations.
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