Arch Neurol. 2012 February 13;
Koo BB, Bergethon P, Qiu WQ, Scott T, Hussain M, Rosenberg I, Caplan LR, Bhadelia RA
BACKGROUND: The Tinetti scale is a simple clinical apparatus designed to predict risk of falling by focusing on gait as well as position impairment in aged persons. Gait impairment is additionally associated with white matter (WM) abnormalities. OBJECTIVE: To exam a hypothesis that aged subjects at risk for falling, as determined by a Tinetti scale, have specific patterns of WM abnormalities on freeing tensor imaging. Design, Setting, as well as Patients Community-based cohort of 125 homebound aged individuals. MAIN OUTCOME MEASURES: Diffusion tensor imaging scans were analyzed regulating tract-based spatial statistics analysis to determine a location of WM abnormalities in subjects with Tinetti scale scores of 25 or aloft (without risk of falls) as well as lower than 25 (with risk of falls). Multivariate linear least squares correlation analysis was performed to determine a association between Tinetti scale scores as well as local fractional anisotropy values on each skeletal voxel controlling for possible confounders. RESULTS: In subjects with risk of falls (Tinetti scale score <25), clusters of abnormal WM were seen in a middle frontal as well as parietal subcortical pathways, genu as well as splenium of corpus callosum, posterior cingulum, prefrontal as well as orbitofrontal pathways, as well as longitudinal pathways that connect frontal-parietal-temporal lobes. Among these abnormalities, those in middle frontal as well as parietal subcortical pathways correlated with Mini-Mental State Examination scores, while a other locations were separate to these scores. CONCLUSIONS: Elderly people at risk for falls as determined by a Tinetti scale have WM abnormalities in specific locations on freeing tensor imaging, some of which correlate with cognitive function scores.
Florida nursing jobs
No comments:
Post a Comment